From Proteopedia

proteopedia linkproteopedia link

This Sandbox is Reserved from January 10, 2010, through April 10, 2011 for use in BCMB 307-Proteins course taught by Andrea Gorrell at the University of Northern British Columbia, Prince George, BC, Canada.

To get started: Click the edit this page tab at the top. Save the page after each step, then edit it again. Click the 3D button (when editing, above the wikitext box) to insert Jmol. show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page. Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc. More help: Help:Editing

spinqualitylabelsall models PDB ID 2iko Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
2iko, resolution 1.90Å ()
Ligands:
Gene:	REN (Homo sapiens)
Activity:	Renin, with EC number 3.4.23.15
Structural annotation: Resources: InterPro : Ipr009007, Ipr001461, Ipr012848, Ipr001969 Pfam : PF00026 UniProt : P00797
Functional annotation: Cellular component: extracellular space membrane Biological process: regulation of MAPKKK cascade regulation of blood pressure proteolysis angiotensin maturation Molecular function: hydrolase activity peptidase activity pepsin A activity renin activity receptor binding aspartic-type endopeptidase activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Contents 1 Introduction 1.1 Structure 1.2 Biochemistry 1.3 Function 2 References

Introduction

(pronounced /ˈriːnɨn/ REE-nin) is also known as angiotensinogenase, a monospecific enzyme that participates in the body's renin-angiotensin system (RAS). Renin is responsible for catalyzing the rate-limiting step in the synthesis of angiotensin II. Once renin and pro-renin bind to the pro-renin receptor, there is an increased enzymatic activity and additional physiological effects. ^[1]

Structure

Renin belongs in the family called aspartic proteases because they use an aspartate residue for catalysis of their peptide substrate.^[1] 3D structure ^[2]

Biochemistry

Renin is an aspartyl protease. ^[3]

spinqualitylabelsall models Insert caption here Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Function

Renin plays a key role in the Renin-Angiotension sysmtem (RAS). This system is responsible for the control of blood pressure and salt balances in mammals.

spinqualitylabelsall models Ligand site Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

References

1. ↑ ^{1.0 1.1} Gradman AH, Kad R. Renin inhibition in hypertension. J Am Coll Cardiol. 2008 Feb 5;51(5):519-28. PMID:18237679 doi:10.1016/j.jacc.2007.10.027
2. ↑ K Akahane, H Umeyama, S Nakagawa, I Moriguchi, S Hirose, K Iizuka, and K Murakami. "Three-dimensional structure of human renin". Hypertension. 1985;7:3-12
3. ↑ Inagami T. Structure and function of renin. J Hypertens Suppl. 1989 Apr;7(2):S3-8. PMID:2666611