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spinqualitylabelsall models PDB ID 2iko Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
2iko, resolution 1.90Å ()
Ligands:
Gene:	REN (Homo sapiens)
Activity:	Renin, with EC number 3.4.23.15
Structural annotation: Resources: InterPro : Ipr009007, Ipr001461, Ipr012848, Ipr001969 Pfam : PF00026 UniProt : P00797
Functional annotation: Cellular component: extracellular space membrane Biological process: regulation of MAPKKK cascade regulation of blood pressure proteolysis angiotensin maturation Molecular function: hydrolase activity peptidase activity pepsin A activity renin activity receptor binding aspartic-type endopeptidase activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Contents 1 Introduction 1.1 Structure 1.2 Biochemistry 1.3 Function 2 References

Introduction

(pronounced /ˈriːnɨn/ REE-nin) is also known as angiotensinogenase, a monospecific enzyme that participates in the body's renin-angiotensin system (RAS). Renin is responsible for catalyzing the rate-limiting step in the synthesis of angiotensin II. Once renin and pro-renin bind to the pro-renin receptor, there is an increased enzymatic activity and additional physiological effects. ^[1]

Structure

Renin belongs in a family called aspartic proteases which use an aspartate residue for the catalysis of their peptide substrate. X-ray diffraction experiments has shown there is a striking similarity among the structures of aspartyl proteases. ^[2] Renin consists of two homologous lobes each containing an aspartic acid. Between the lobes is the active site, which is catalyzed by the aspartic acid residues, a characteristic trait of all aspartate proteases. ^[1] Renin in its full mature form has a mass of 37 kDa and contains 340 amino acids.^[3]

Biochemistry

Renin is an aspartyl protease. ^[4]

spinqualitylabelsall models Insert caption here Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Function

Renin plays a key role in the Renin-Angiotension sysmtem (RAS). This system is responsible for the control of blood pressure and salt balances in mammals.

spinqualitylabelsall models Ligand site Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

References

1. ↑ ^{1.0 1.1} Gradman AH, Kad R. Renin inhibition in hypertension. J Am Coll Cardiol. 2008 Feb 5;51(5):519-28. PMID:18237679 doi:10.1016/j.jacc.2007.10.027
2. ↑ K Akahane, H Umeyama, S Nakagawa, I Moriguchi, S Hirose, K Iizuka, and K Murakami. "Three-dimensional structure of human renin". Hypertension. 1985;7:3-12
3. ↑ Armstrong C. The vision of the pore. Science. 1998 Apr 3;280(5360):56-7. PMID:9556453
4. ↑ Inagami T. Structure and function of renin. J Hypertens Suppl. 1989 Apr;7(2):S3-8. PMID:2666611