User:Daniel Parrell/Sandbox 1
From Proteopedia
Aquaporin 4
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The discovery of aquaporin channels was a brakthrough discovery relating to water transport in cells. Peter Agre's discovery of the aquaporin channel family, answered a key question that had stumped biochmesists and cell biologists for years. This was the question of how is water abe to transport across the hydrophobic lipid bilayer so efficiently? When experimentally determined, the rate of water transport is able to occure at a rate of about 10^9 molecules per second, this is many times the limit set by diffusion across the membrane. There are 13 known mammalian aquaporins. Each is expressed in different tissues, and serve different functions based of the common theme of water balance.
Aquaporin 4 (3GD8) is a part of the aquaporin family. Mostly expressed in brain astrocytes, it contains the same structural and functionla motifs typical of the aquaporins. The
Structure
One of the defining features of aquaporins, and of Aquaporin 4 is the ,its amino acids, and how it interacts, through hydrogen bonding,to drive create water transport.
