G protein-coupled receptor

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G protein-coupled receptors, often abbreviated GPCRs, are an abundant class of proteins also known as seven-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein-linked receptors (GPLRs).

[[G protein-coupled receptor|G protein-coupled receptors] are involved in many diseases, and are also the target of approximately 30% of all modern medicinal drugs ^[1].

Contents 1 See Also 2 3D Structures of G protein-coupled receptors 3 References and Notes 4 Additional Literature 5 External Resources

See Also

Pharmaceutical Drugs

3D Structures of G protein-coupled receptors

References and Notes

1. ↑ Overington JP, Al-Lazikani B, Hopkins AL. How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. PMID:17139284 doi:10.1038/nrd2199

Additional Literature

• PMID: xxxx

External Resources

• GPCRDB: database contains sequences, ligand binding constants and mutations, in addition GPCR multiple sequence alignments and homology models. Moreover, the site contains useful structure files where lysozyme and other inserts commonly used in the difficult process of crystallizing these transmembrane structures are removed.
• tinyGRAP GPCR mutant database.
• GPCR-OKB: GPCR Oligomerization Knowledge Base
• GPCR Natural Variants Database (NaVa)
• The PRED-GPCR server for GPCR recognition and family classification.