G protein-coupled receptor

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G protein-coupled receptors, often abbreviated GPCRs, are an abundant superamily of proteins also known as seven-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein-linked receptors (GPLRs). G protein-coupled receptors are cell surface signalling proteins involved in many physiological functions and in multiple diseases. they are also the target of the majority of all modern medicinal drugs ^[1][2].

Contents 1 See Also 2 3D Structures of G protein-coupled receptors 3 References and Notes 4 Additional Literature 5 External Resources

See Also

Pharmaceutical Drugs

3D Structures of G protein-coupled receptors

3eml 2vt4 2r4r 2r4s 2rh1 3d4s 3kj6 3ny8 3ny9 3nya 1bl1 1d6g 1ddv 1dep

1eds - solution structure of intradiskal loop 1 of bovine rhodopsin (rhodopsin residues 92-123 1edv 1edw 1edx 1ewk 1ewt 1ewv 1f88 1fdf 1fjr 1gzm 1hll 1ho9 1hod 1hof 1hzn

References and Notes

1. ↑ Overington JP, Al-Lazikani B, Hopkins AL. How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. PMID:17139284 doi:10.1038/nrd2199
2. ↑ Peeters MC, van Westen GJ, Li Q, IJzerman AP. Importance of the extracellular loops in G protein-coupled receptors for ligand recognition and receptor activation. Trends Pharmacol Sci. 2011 Jan;32(1):35-42. PMID:21075459 doi:10.1016/j.tips.2010.10.001

Additional Literature

• PMID: xxxx

External Resources

• GPCRDB: database contains sequences, ligand binding constants and mutations, in addition GPCR multiple sequence alignments and homology models. Moreover, the site contains useful structure files where lysozyme and other inserts commonly used in the difficult process of crystallizing these transmembrane structures are removed.
• tinyGRAP GPCR mutant database.
• GPCR-OKB: GPCR Oligomerization Knowledge Base
• GPCR Natural Variants Database (NaVa)
• The PRED-GPCR server for GPCR recognition and family classification.