Complexes

From Proteopedia

Multi-protein assemblies

Many PDB files contain complexes in which a biological molecule is interacting with another biological molecule in a complex or assembly. These interactions, if biologically relevant, can be immensely insightful in shedding light on cellular and extracellular processes.

Examples

• Ribosome
• T7 RNA Polymerase
• Mouse Toll-like receptor bound to dsRNA
• Human Follicle-Stimulating Hormone Complexed with its Receptor
• Platelet-receptor glycoprotein Ib alpha bound to the von Willebrand Factor A1 Domain
• Plant Viral Protein p19 Suppression of RNA Silencing
• RecG Bound to Three-Way DNA Junction

See Also

• Multi-protein assemblies
• Biological assembly
• Crystal contacts
• X-ray crystallography
• Ligand

External Resources

• PICCOLO, a comprehensive relational database featuring the details of structurally characterized protein-protein interactions.
• PRO provides an ontological representation of proteins in complexes. In particular, the authors are working to implement logical and consistent representation of protein complexes.
• COCOMAPS (bioCOmplexes COntact MAPS) is a web server for analysis and visualization of the interfaces present in biological complexes, such as protein-protein, protein-DNA and protein-RNA complexes, making use of intermolecular contact maps.
• The HADDOCK web server is web server for data-driven biomolecular docking for modeling of biomolecular complexes.

Literature Citations

Literature citations can be found at the respective servers linked above.