Amino acid oxidase

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Amino acid oxidase catalyzes the oxidation of amino acids to the keto acid producing ammonia and hydrogen peroxide. These enzymes oxidize D-amino acids (DAO) and L-amino acids (LAO). The LAO oxidation products are 2-oxo acid, ammonia and hydrogen peroxide. LAO is widely found in snake venom. DAOs oxidize neutral and basic D-amino acids. Some DAOs are used in cancer therapy as inducers of oxidative stress and apoptosis. DAO and LAO use FAD as a cofactor.

3D structures of amino acid oxidase

D-amino acid oxidase

1kif – pDAO – pig
1c0l – RtDAO – Rhodosporidium toruloides
1dao – pDAO + methyl-oxo-valeric acid
1ddo – pDAO + imino-tryptophan
1an9 – pDAO + aminobenzoate
1ve9 - pDAO + benzoate
1evi – pDAO + dihydro-pyrrolium-carboxylate
1c0x – RtDAO + L-lactate
1c0p – RtDAO + peroxide
1c0i - RtDAO + aminobenzoate

L-amino acid oxidase

2jae – RoLAO – Rhodococcus opacus
1f8r – CrLAO + citrate – Calloselasma rhodostoma
1f8s - CrLAO + aminobenzoate
1tdk – HvLAO + L-vinylglycine – Halys viper
1tdn - HvLAO + L-leucine
1tdo - HvLAO + L-phenylalanine
2jb1 - RoLAO + L-alanine
2jb2 - RoLAO + L-phenylalanine
2jb3 - RoLAO + aminobenzoate
3kve – LAO + Zn – Vipera ammodytes

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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