User:Anika Zohra Yasin/Sandbox1 3pb3

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Contents 1 Introduction 2 Biological Source 3 Structure 4 Sequence 5 Function 6 Conclusion 7 References

Introduction

3Pb3 is a 16S rRNA methyltransferase. It methylates one nucleotide in bacterial ribosomes, creating resistance to some aminoglycoside antibiotics. This enzyme is part of the kanamycin-apramycin methyltransferase (Kam) family.

Biological Source

• E. Coli

Structure

Sequence

• Ligand Information: S-ADENOSYL-L-HOMOCYSTEINE(SAH)

Function

• Methyltransferase Activity

3pb3 acts as a methyltransferase also known as methylase which adds a methyl group to specific bases in their ribosomes.

• Antibiotic Resistance

The antibiotic is unable to bind to the ribosomes rendering it ineffective.

Conclusion

References