Sandbox Reserved 482

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Revision as of 18:11, 27 April 2012 by Elin M. Pola (Talk | contribs)
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This Sandbox is Reserved from 13/03/2012, through 01/06/2012 for use in the course "Proteins and Molecular Mechanisms" taught by Robert B. Rose at the North Carolina State University, Raleigh, NC USA. This reservation includes Sandbox Reserved 451 through Sandbox Reserved 500.
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Syntaxin-1A

Introduction

Syntaxin-1A is part of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) family. It is an integrin plasma membrane protein found almost exclusively in neurons and it is known for its essential roles in neuronal signaling. (1) It assembles in tight core complexes, which promote fusion of carrier vesicles with target compartments. Members of the SNARE class of proteins are expressed in all eukaryotic cells and are distributed in distinct subcellular compartments. (2)

The neurodevelopmental disorder Williams syndrome is caused by the haploinsufficiency of genes. It is caused by deletion of genetic material. The deleted region has now been identified and syntaxin-1A is one of the genes that has been deleted. (3)


Structure

Function

Applications

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