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Lipase lid morph

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Revision as of 10:41, 14 May 2012 by Eric Martz (Talk | contribs)
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Candida rugosa lipase (1trh, 1lpm).

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For an introduction to the structure and function of lipase, please see the article Lipase. This Lipase lid morph article is a supplement to the main article on Lipase.

Candida rugosa lipase (triacylglycerol hydrolase) has been observed in two conformations, with the "lid" closed (1trh) or open (1lpm)[1]. A morph[2] shows the lid opening and closing.

When open, substrate can access the catalytic triad, Ser209, Glu341, and His449[1]

See Also

Notes and References

  1. ↑ 1.0 1.1 Grochulski P, Li Y, Schrag JD, Cygler M. Two conformational states of Candida rugosa lipase. Protein Sci. 1994 Jan;3(1):82-91. PMID:8142901
  2. ↑ This is a linear interpolation morph. The 14-model PDB file is Image:Morph-linear-1trh-1lpm.pdb.gz.

Proteopedia Page Contributors and Editors (what is this?)

Eric Martz, Karsten Theis

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