1acj

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spinqualitylabelsall models PDB ID 1acj Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1acj, resolution 2.80Å ()
Ligands:
Activity:	Acetylcholinesterase, with EC number 3.1.1.7
Structural annotation: Resources: CATH : 1Acj000 InterPro : Ipr002018, Ipr000908, Ipr000997 Pfam : PF00135 SCOP : d1acj__ UniProt : P04058
Functional annotation: Cellular component: cell junction membrane synapse Biological process: neurotransmitter catabolic process acetylcholine catabolic process in synaptic cleft Molecular function: GPI anchor binding cholinesterase activity acetylcholinesterase activity hydrolase activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Contents 1 QUATERNARY LIGAND BINDING TO AROMATIC RESIDUES IN THE ACTIVE-SITE GORGE OF ACETYLCHOLINESTERASE 2 About this Structure 3 See Also 4 Reference

QUATERNARY LIGAND BINDING TO AROMATIC RESIDUES IN THE ACTIVE-SITE GORGE OF ACETYLCHOLINESTERASE

Template:ABSTRACT PUBMED 8415649

About this Structure

1acj is a 1 chain structure of Acetylcholinesterase with sequence from Torpedo californica. The June 2004 RCSB PDB Molecule of the Month feature on Acetylcholinesterase by David S. Goodsell is 10.2210/rcsb_pdb/mom_2004_6. Full crystallographic information is available from OCA.

See Also

• AChE bivalent inhibitors
• AChE inhibitors and substrates
• AChE inhibitors and substrates (Part II)
• Acetylcholinesterase
• Acetylcholinesterase complexed with N-9-(1'%2C2'%2C3'%2C4'-tetrahydroacridinyl)-1%2C8-diaminooctane
• Alzheimer's Disease
• Demo 1acj
• Quiz Template
• Sandobx 1997
• Torpedo Californica Acetylcholinesterase in complex with an (R)-Tacrine-(10)-Hupyridone inhibitor
• Torpedo californica acetylcholinesterase with alkylene-linked tacrine dimer (5 carbon linker)
• Torpedo californica acetylcholinesterase with alkylene-linked tacrine dimer (7 carbon linker)
• UMass Chem 423 Student Projects 2011-1
• User:Mary Ball/Glucagon
• User:Mary Ball/Leptin
• User:Mary Ball/Scenes

Reference

• Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649
• Pomponi M, Marta M, Colella A, Sacchi S, Patamia M, Gatta F, Capone F, Oliverio A, Pavone F. Studies on a new series of THA analogues: effects of the aromatic residues that line the gorge of AChE. FEBS Lett. 1997 Jun 9;409(2):155-60. PMID:9202137