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HIV-1 protease

by David Canner

The X-ray structure of HIV-1 protease reveals that it is composed of , each consisting of 99 amino acid residues. The subunits come together in such as way as to . This tunnel is of critical importance because the active site of the protease is located in its interior. The active site consists of , making it a member of the aspartyl protease family. The two Asp's are either interact with the incoming water OR protonate the carbonyl to make the carbon more electrophilic for the incoming . (more...)

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How to display cavities, pockets, and tunnels.

March 2024: Professors are using Proteopedia for class projects in Brazil, Czech Republic, France, and various states in the USA. See the updated Adoptions in College and University Classes.
What happens if a SARS-CoV-2 coronavirus enters your lung? See a clear explanation at Lifecycle of SARS-CoV-2
July 2022: Exercise-induced N-lactoyl-phenylalanine, appetite and obesity
5,000 users!! On December 4, 2021, the number of Proteopedia users went over 5,000. The 5,000th user is from Juniata College, Huntingdon, Pennsylvania, US
AlphaFold protein structure predictions - a step change for biology, an electronic talk by EBI staff for students and early career researchers via FEBS Junior Sections, Oct. 26, 2021, 19:00 CEST. Announcement. Registration.
A practical guide to teaching with Proteopedia ^[1]
January 2021: How to display cavities, pockets, and tunnels? Jmol/Cavities_pockets_and_tunnels
December 2020: What is changing on SARS-CoV-2 virus and what this means for humanity? SARS-CoV-2 spike protein mutations.
August 2020: An animation of coronavirus spike protein showing the SARS-CoV-2 spike protein fusion transformation.
July 2020: An animation of coronavirus spike protein showing SARS-CoV-2 protein S priming by furin.
March 2020: New Proteopedia page focused on the Coronavirus 2019 (COVID-19).
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↑ Castro C, Johnson RJ, Kieffer B, Means JA, Taylor A, Telford J, Thompson LK, Sussman JL, Prilusky J, Theis K. A practical guide to teaching with Proteopedia. Biochem Mol Biol Educ. 2021 Jun 3. doi: 10.1002/bmb.21548. PMID:34080750 doi:http://dx.doi.org/10.1002/bmb.21548

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