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1qk9

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Image:1qk9.png

Template:STRUCTURE 1qk9

Contents

THE SOLUTION STRUCTURE OF THE DOMAIN FROM MECP2 THAT BINDS TO METHYLATED DNA

Template:ABSTRACT PUBMED 10518942

About this Structure

1qk9 is a 1 chain structure of Methyl CpG Binding Protein 2 with sequence from Homo sapiens. Full experimental information is available from OCA.

See Also

Reference

  • Wakefield RI, Smith BO, Nan X, Free A, Soteriou A, Uhrin D, Bird AP, Barlow PN. The solution structure of the domain from MeCP2 that binds to methylated DNA. J Mol Biol. 1999 Sep 3;291(5):1055-65. PMID:10518942 doi:10.1006/jmbi.1999.3023
  • Hendrich B, Bird A. Identification and characterization of a family of mammalian methyl-CpG binding proteins. Mol Cell Biol. 1998 Nov;18(11):6538-47. PMID:9774669
  • Nan X, Ng HH, Johnson CA, Laherty CD, Turner BM, Eisenman RN, Bird A. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature. 1998 May 28;393(6683):386-9. PMID:9620804 doi:10.1038/30764
  • Bird AP. The relationship of DNA methylation to cancer. Cancer Surv. 1996;28:87-101 PMID:8977030
  • Nilges M. Calculation of protein structures with ambiguous distance restraints. Automated assignment of ambiguous NOE crosspeaks and disulphide connectivities. J Mol Biol. 1995 Feb 3;245(5):645-60. PMID:7844833 doi:http://dx.doi.org/10.1006/jmbi.1994.0053
  • Boyes J, Bird A. DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein. Cell. 1991 Mar 22;64(6):1123-34. PMID:2004419 doi:10.1016/0092-8674(91)90267-3
  • Bird AP. CpG-rich islands and the function of DNA methylation. Nature. 1986 May 15-21;321(6067):209-13. PMID:2423876 doi:http://dx.doi.org/10.1038/321209a0

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