Sandbox 31

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Please do NOT make changes to this Sandbox. Sandboxes 30-60 are reserved for use by Biochemistry 410 & 412 at Messiah College taught by Dr. Hannah Tims during Fall 2012 and Spring 2013.

Contents 1 Adenylate Kinase (PDB ID #: 1ake) 2 Introduction 3 Physical Properties 4 Structure 5 Active Site and Mechanism 6 References

Adenylate Kinase (PDB ID #: 1ake)

spinqualitylabelsall models adenylate kinase bound to non-hydrolyzable substrate analogue Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Introduction

is a good little protein.

Physical Properties

Adenylate kinase is caged with .

Structure

The of adenylate kinase shows alpha helicies (cyan) and beta sheets (green) surrounding the non-hydrolyzable substrate analogue (orange). Adenylate kinase has a exterior, and a core, with additional on the interior contacting the ligand.

Active Site and Mechanism

residues within of the ligand are involved in binding the ligand or stabilizing the active site.

adenylate kinase's is highlighted in dark blue.

together you can see that the is only a fraction of the molecules involved in binding the ligand.

spinqualitylabelsall models Cryptosporidium parvum Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Comparing the E.coli structure to

References