1j3j

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Template:STRUCTURE 1j3j

Contents 1 Double mutant (C59R+S108N) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with pyrimethamine, NADPH, and dUMP 2 About this Structure 3 See Also 4 Reference

Double mutant (C59R+S108N) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with pyrimethamine, NADPH, and dUMP

Template:ABSTRACT PUBMED 12704428

About this Structure

1j3j is a 4 chain structure with sequence from Plasmodium falciparum. Full crystallographic information is available from OCA.

See Also

• Dihydrofolate reductase
• Thymidylate synthase

Reference

• Yuvaniyama J, Chitnumsub P, Kamchonwongpaisan S, Vanichtanankul J, Sirawaraporn W, Taylor P, Walkinshaw MD, Yuthavong Y. Insights into antifolate resistance from malarial DHFR-TS structures. Nat Struct Biol. 2003 May;10(5):357-65. PMID:12704428 doi:10.1038/nsb921