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N-Acetylglutamate synthase

Introduction

N-Acetylglutamate synthase (NAGS) is a mitochondrial enzyme involved in the Urea Cycle. This enzyme is most directly used in the conversion of glutamate (glutamic acid) and Coenzyme A into N-Acetylglutamate (NAG). N-Acetylglutamate synthase was first discovered as a mammalian liver enzyme but has very low rate of conservation across phyla.

In mammals, N-Acetylglutamate synthase modulates Carbamoyl phosphate synthetase I which is the first rate limiting enzyme in the Urea cycle. Arginine greatly up regulates the activity of NAGS in mammals. Human NAGS is synthesized as a preprotein of 534 amino acids [1]. There is only 63% identity between the mouse NAGS and human NAGS.

In bacteria and fungi NAGS is inhibited by arginine.

Structure

Mechanism of action

Implications or possible application

References

Footnotes