Sandbox Reserved 652

• Click the edit this page tab at the top. Save the page after each step, then edit it again.
• Click the 3D button (when editing, above the wikitext box) to insert Jmol.
• show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
• Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

For more help, look at this link: http://proteopedia.org/w/Help:Getting_Started_in_Proteopedia

Alanine Aminotransferase

spinqualitylabelsall models PDB ID 3ihj Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
3ihj, resolution 2.30Å ()
Ligands:	,
Gene:	GPT2, AAT2, ALT2 (Homo sapiens)
Activity:	Alanine transaminase, with EC number 2.6.1.2
Structural annotation: Resources: InterPro : Ipr004839, Ipr015424, Ipr015422, Ipr015421 Pfam : PF00155
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Introduction

Alanine aminotransferase (ALT), also known as L-alanine:α-ketoglutarate aminotransferase (EC 2.6.1.2); and also formerly known as alanine transaminase, is an intracellular cytoplasmic enzyme, which is found in greatest quantities in the liver and kidneys. ALT's main function is to catalyze the transfer of amino groups from alanine to form pyruvate from α-ketoglutarate, which is a key intermediate of gluconeogenesis. Levels of ALT are often quantified in humans to measure liver damage from inflammation or necrosis. High levels of ALT could be a response to high alcohol intake, obesity, diabetes, and other liver conditions. Quantification of ALT is limited because it is only able to identify liver damage but not the cause of the liver damage.