This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Fatty acid synthase
From Proteopedia
Fatty acid synthase (FAS) catalizes the synthesis of palmitate from acetyl CoA and malonyl CoA into long chain fatty acid. FAS is a multi-domain enzyme. It contains an acyl carrier protein domain (ACP).
3D structures of fatty acid synthase
Updated on 07-March-2013
1kp9 – MtFAS CmaA1 – Mycobacterium tuberculosis
1xkt – hFAS thioesterase domain – human
2jfd – hFAS MAT domain
3hhd - hFAS KS-MAT domain
2cf2, 2vz8 – pFAS – pig
2uv8, 3hmj – yFAS α+β subunits - yeast
2pff, 2was – yFAS α subunit
2uv9 – TlFAS α subunits – Thermomyces lanuginosus
2uva – TlFAS β subunits
2png – FAS ACP domain – rat
1t8k – EcFAS ACP domain - Escherichia coli
2k92, 2k93, 2k94 - EcFAS ACP domain – NMR
FAS complex with fatty acid
1kpg – MtFAS CmaA1 + cetyl-trimethyl-ammonium + adenosyl homocysteine
1kph – MtFAS CmaA1 + didecyl-dimethyl-ammonium + adenosyl homocysteine
1kpi – MtFAS CmaA2 + didecyl-dimethyl-ammonium + adenosyl homocysteine
3hem - MtFAS CmaA1 + dioctylamine
3tjm – hFAS thioesterase domain + fatty acid
2fae – EcFAS ACP domain + decanethioate
2fad – EcFAS ACP domain + heptanthioate
FAS complex with reactants
2jfk – hFAS + malonyl CoA
2uvc – TlFAS β subunits + NADP
2uvb – TlFAS α subunits + NADP
2wat – yFAS α subunit + CoA
2vzp – pFAS + NADP
FAS complex with protein
2fhs – EcFAS ACP domain + enoyl-ACP reductase
3ejb - EcFAS ACP domain + biotin biosynthesis cytochrome P450-like enzyme
3ejb, 3eje - EcFAS ACP domain + biotin biosynthesis cytochrome P450-like enzyme + fatty acid
2cg5 - hFAS ACP domain + AASD-PPT
FAS complex with inhibitor
2vkz - yFAS α+β subunits + cerulenin
