4g8z

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Template:STRUCTURE 4g8z

Contents

pcDHFR K37S/F69N double mutant TMP NADPH ternary complex

Template:ABSTRACT PUBMED 23545530

Function

[DYR_PNECA] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

About this Structure

4g8z is a 1 chain structure with sequence from Pneumocystis jirovecii. Full crystallographic information is available from OCA.

Reference

  • Cody V, Pace J, Queener SF, Adair OO, Gangjee A. Kinetic and Structural Analysis for Potent Antifolate Inhibition of Pneumocystis jirovecii, Pneumocystis carinii, and Human Dihydrofolate Reductases and Their Active-Site Variants. Antimicrob Agents Chemother. 2013 Jun;57(6):2669-77. doi: 10.1128/AAC.00172-13., Epub 2013 Apr 1. PMID:23545530 doi:10.1128/AAC.00172-13

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OCA

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