2voy
From Proteopedia
Contents |
CryoEM model of CopA, the copper transporting ATPase from Archaeoglobus fulgidus
Template:ABSTRACT PUBMED 18547529
Function
[COPA_ARCFU] Probably involved in copper and silver export.[1] [AT2A1_RABIT] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction (By similarity). [COPA_BACSU] Involved in copper export.[2]
About this Structure
2voy is a 12 chain structure with sequence from Archaeoglobus fulgidus, Bacillus subtilis and Oryctolagus cuniculus. Full crystallographic information is available from OCA.
Reference
- Wu CC, Rice WJ, Stokes DL. Structure of a copper pump suggests a regulatory role for its metal-binding domain. Structure. 2008 Jun;16(6):976-85. PMID:18547529 doi:http://dx.doi.org/10.1016/j.str.2008.02.025
- ↑ Mandal AK, Cheung WD, Arguello JM. Characterization of a thermophilic P-type Ag+/Cu+-ATPase from the extremophile Archaeoglobus fulgidus. J Biol Chem. 2002 Mar 1;277(9):7201-8. Epub 2001 Dec 26. PMID:11756450 doi:10.1074/jbc.M109964200
- ↑ Radford DS, Kihlken MA, Borrelly GP, Harwood CR, Le Brun NE, Cavet JS. CopZ from Bacillus subtilis interacts in vivo with a copper exporting CPx-type ATPase CopA. FEMS Microbiol Lett. 2003 Mar 14;220(1):105-12. PMID:12644235
