3k74

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Template:STRUCTURE 3k74

Contents 1 Disruption of protein dynamics by an allosteric effector antibody 2 Function 3 About this Structure 4 See Also 5 Reference

Disruption of protein dynamics by an allosteric effector antibody

Template:ABSTRACT PUBMED 21238460

Function

[DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

About this Structure

3k74 is a 2 chain structure with sequence from Escherichia coli k-12 and Lama glama. Full crystallographic information is available from OCA.

See Also

• Dihydrofolate reductase

Reference

• Oyen D, Srinivasan V, Steyaert J, Barlow JN. Constraining enzyme conformational change by an antibody leads to hyperbolic inhibition. J Mol Biol. 2011 Mar 18;407(1):138-48. Epub 2011 Jan 14. PMID:21238460 doi:10.1016/j.jmb.2011.01.017