Sandbox Reserved 786

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This Sandbox is Reserved from Oct 10, 2013, through May 20, 2014 for use in the course "CHEM 410 Biochemistry 1 and 2" taught by Hanna Tims at the Messiah College. This reservation includes Sandbox Reserved 780 through Sandbox Reserved 807.

To get started: Click the edit this page tab at the top. Save the page after each step, then edit it again. Click the 3D button (when editing, above the wikitext box) to insert Jmol. show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page. Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc. More help: Help:Editing

spinqualitylabelsall models Malate Dehydrogenase Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

The shows that it is a homo-tetramer. However the is a dimer. In the image, the alpha-helices are green, Beta-sheets are red, and random coils (turns) are grey.

Secondary Structure

The is formed by hydrogen bonding interactions of the amino acids backbone. There are two beta-sheet regions in each monomer of the natural dimer. Five beta-sheets in each monomer are anti-parallel, and form a pseudo beta-barrel motif. Six beta-sheets in each monomer show parallel configuration. The angle of the hydrogen bonds relative to one another between beta-sheets gives insight as to which beta-sheets are parallel and which are anti-parallel. Parallel beta-sheets have "crooked" h-bonding. This makes them more unstable than the anti-parallel beta-sheets which have straight h-bonds between them.