Albumin

From Proteopedia

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spinqualitylabelsall models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Albumin (Alb) is water-soluble protein. Serum albumin (SA) is the most abundant blood plasma protein. SA serves as carrier of fatty acids, bilirubin, ions and drugs. For details on human serum albumin see User:Neeharika Pothuri/Human Serum Albumin STRUCTURE 1BM0. Investigation on the Site-Selective Binding of Bovine Serum Albumin by Erlotinib Hydrochloride [1] The binding mode of , a targeted anticancer drug, to was investigated through 1H NMR, spectroscopic, thermodynamic and molecular modeling methods. Each subdomain is marked with a different colour (red for subdomain IA; orange, IB; cyan, IIA; yellow, IIB; green, IIIA; darkmagenta, IIIB). From these methods, the binding parameters, binding site, binding distance, and conformational changes were obtained. Site marker competitive experiments demonstrated that the . The docking modeling agreed with the results of the fluorescence and displacement experiments.

3D Structures of albumin

Updated on 13-November-2013

Human serum albumin

1e78, 1bm0, 1ao6, 1uor, 4g03, 4g04, 4k2c - hSA – human

Human serum albumin binary complex

2ydf – hSA + iophenoxic acid
2xvq, 2xvu, 2xw0, 2xw1 - hSA + dansyl derivative
3lu6, 3ju7, 3lu8, 2bx8, 2bxa, 2bxb, 2bxc, 2bxd, 2bxe, 2bxf , 2bxg, 2bxh, 2bxi, 2bxk, 2bxl, 2bxm, 2bxn, 2bxo, 2bxp, 2bxq, 3lu7, 4l8u, 4l9q, 4la0, 4lb2, 4lb9 – hSA + drug
4iw1, 4iw2 – hSA + monosaccharide
3jqz – hSA + lidocaine
3jry - hSA + sulfate
4emx – has + Cl
1n5u - hSA + heme
3a73 - hSA + prostaglandin
2vuf, 2vue - hSA + bilirubin derivative
1gni, 1gnj, 1e7h, 1e7e, 1e7f, 1e7i, 1bke, 1bj5, 3tdl, 4e99 - hSA + fatty acid
1hk1 - hSA + thiroxine
2hk2, 1hk3, 1hk2 - hSA (mutant) + thiroxine
1e7a, 1e7b - hSA + general anesthetic
1tf0 - hSA + peptostreptococcal albumin-binding protein GA module
2esg - hSA + immunoglobulin A1
1ysx - hSA + anti-apoptotic ligand – NMR
4hgk, 4hgm – hSA + shark antibody

Human serum albumin ternary complex

2xsi, 2xvv, 2xvw – hSA + dansyl derivative + myristic acid
3cx9 - hSA + lysophospholipid + myristic acid
1e7g - hSA + fatty acid + myristic acid
1h9z, 1ha2 - hSA + warfarine + myristic acid
1e7c - hSA + general anesthetic + myristic acid
1hk4 - hSA + thiroxine + myristic acid
1hk5 - hSA (mutant) + thiroxine + myristic acid
1o9x - hSA + hemin + myristic acid
3uiv - hSA + amantadine + myristic acid
3b9l - hSA + AZT + myristic acid
2i2z - hSA + aspirin + myristic acid
2i30 - hSA + salicylic acid + myristic acid
3b9m - hSA + AZT + salicylic acid + myristic acid
2vdb - hSA + peptostreptococcal albumin-binding protein GA module + naproxen

Other serum albumin

3v03, 4f5s - bSA – bovine
3v08, 4f5t, 4f5u – hoSA – horse
3v09, 4f5u – SA – rabbit
3vvj – SA – emu
4j2v – hoSA + diiodosalicilate
4jk4 – bSA + diiodosalicilate

Albumin

1s6d – Alb 8 – sunflower – NMR
1wba – Alb 1 – winged bean
1p8b – Alb 1 – pea
1psy – Alb – castor bean - NMR
3lp9 – Alb hemopexin domain – Lathyrus sativus
2lvf – Alb – Brazil nut

References

1. ↑ Liu Y, Chen M, Luo Z, Lin J, Song L. Investigation on the site-selective binding of bovine serum albumin by erlotinib hydrochloride. J Biomol Struct Dyn. 2012 Oct 17. PMID:23072300 doi:10.1080/07391102.2012.726532