3jw3

From Proteopedia

proteopedia linkproteopedia link

Template:STRUCTURE 3jw3

Contents 1 Crystal structure of Bacillus anthracis (F96I) dihydrofolate reductase complexed with NADPH and Trimethoprim 2 Function 3 About this Structure 4 See Also 5 Reference

Crystal structure of Bacillus anthracis (F96I) dihydrofolate reductase complexed with NADPH and Trimethoprim

Function

[Q81R22_BACAN] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194]

About this Structure

3jw3 is a 2 chain structure with sequence from "bacillus_cereus_var._anthracis"_(cohn_1872)_smith_et_al._1946 "bacillus cereus var. anthracis" (cohn 1872) smith et al. 1946. Full crystallographic information is available from OCA.

See Also

• Dihydrofolate reductase

Reference

• Beierlein JM, Karri NG, Anderson AC. Targeted mutations of Bacillus anthracis dihydrofolate reductase condense complex structure-activity relationships. J Med Chem. 2010 Oct 28;53(20):7327-36. PMID:20882962 doi:10.1021/jm100727t