3f0q

From Proteopedia

proteopedia linkproteopedia link

Template:STRUCTURE 3f0q

Contents 1 Staphylococcus aureus dihydrofolate reductase complexed with NADPH and 2,4-Diamino-5-[3-(3-methoxy-5-(2,6-dimethylphenyl)phenyl)but-1-ynyl]-6-methylpyrimidine 2 Function 3 About this Structure 4 See Also 5 Reference

Staphylococcus aureus dihydrofolate reductase complexed with NADPH and 2,4-Diamino-5-[3-(3-methoxy-5-(2,6-dimethylphenyl)phenyl)but-1-ynyl]-6-methylpyrimidine

Template:ABSTRACT PUBMED 20643959

Function

[Q2YY41_STAAB] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194]

About this Structure

3f0q is a 1 chain structure with sequence from Staab. Full crystallographic information is available from OCA.

See Also

• Dihydrofolate reductase

Reference

• Frey KM, Georgiev I, Donald BR, Anderson AC. Predicting resistance mutations using protein design algorithms. Proc Natl Acad Sci U S A. 2010 Jul 19. PMID:20643959