Vitamin D receptor (VDR) is a transcription factor. Upon binding to vitamin D, VDR forms a heterodimer with retinoid-X receptor and binds to hormone response receptors on DNA causing gene expression. VDR contains a ligand binding domain (LBD) and DNA-binding domain (DBD).
3D structures of vitamin D receptor
Updated on 02-December-2013
Vitamin D receptor ligand-binding domain
3m7r - hVDR LBD (mutant) – human
1db1 – hVDR LBD + vitamin D
1s0z, 1s19, 3a78, 4g2i - hVDR LBD + vitamin D derivative
3ogt, 2ham, 2har, 2has, 2hb7, 2hb8, 3p8x, 3az1, 3az2, 3az3, 3tkc - hVDR LBD + vitamin D analog
3auq, 3aur, 3kpz - hVDR LBD (mutant) + vitamin D analog
3a2i, 3a2j, 3b0t, 3ax8, 3vhw - hVDR LBD (mutant) + vitamin D derivative
3a3z, 3a40 - hVDR LBD + agonist
1ie8, 1ie9, 3cs4, 3cs6, 1txi – hVDR LBD + superagonist
3w5q, 3w5r, 3w5t - hVDR LBD + lithocholic acid derivative
Vitamin D receptor LBD complex with peptide
1rjk, 1rk3, 1rkg, 1rkh, 2o4j, 2o4r – rVDR LBD (mutant) + peroxisome proliferator-activated receptor peptide – rat
2zl9, 2zla, 2zlc - rVDR LBD + coactivator peptide DRIP + vitamin D analog
3vrt, 3vru, 3vrv, 3vrw - rVDR LBD (mutant) + coactivator peptide DRIP + vitamin D analog
2zfx, 3a2h, 2zxm, 2zxn - rVDR LBD + coactivator peptide DRIP
3aun, 2zmh, 2zmi, 2zmj, 3afr, 3vjs, 3vjt - rVDR LBD (mutsant) + coactivator peptide DRIP
2hbh - zVDR LBD + steroid receptor coactivator 1 peptide – zebrafish
2hc4 - zVDR LBD + steroid receptor coactivator 1 peptide + vitamin D
2hcd - zVDR LBD + steroid receptor coactivator 1 peptide
Vitamin D receptor DNA-binding domain
1kb2 – hVDR DBD + osteopontin response element DNA
1kb4 – hVDR DBD + DR3 response element DNA
1ynw – hVDR DBD (mutant) + DR3 response element DNA
1kb6 – hVDR DBD + osteocalcin response element DNA
