Deoxycytidine kinase

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Image:1p62.png
Crystal structure of human deoxycytidine kinase complex with ADP and chemotherapy agent 1p62

Template:STRUCTURE 1p62













Deoxycytidine kinase (DCK) is required for the phosphorylation of deoxyribonucleosides dC, dG and dA and nucleosides analogs which are used as antiviral and chemotherapeutic agents. Deficiency of DCK causes resistance to these agents.

Contents

3D Structures of deoxycytidine kinase

Updated on 08-December-2013

dCK complex with chemotherapy agent

1p5z, 1p62, 2a7q – hDCK + ADP + chemotherapy agent – human
2no9, 2noa, 2no0, 2no6, 2zi9 – hDCK (mutant) + ADP + chemotherapy agent
2zia – hDCK (mutant) + UDP + chemotherapy agent

dCK complex with nucleoside

1p60, 1p61, 3kfx – hDCK + ADP + dC
2no1, 2no7 – hDCK (mutant) + ADP + dC
2zi3, 2zi4 – hDCK (mutant) + ADP + dA
3hp1 – hDCK (mutant) + ADP + dT
2zi5, 2zi6 – hDCK (mutant) + UDP + dA
2zi7 – hDCK (mutant) + UDP + dG
2a2z, 3qen – hDCK (mutant) + UDP + dC
3qeo – hDCK (mutant) + UDP + dT
2a30 – hDCK (mutant) + dC

Other dCK complexes

2qrn – hDCK + UDP + CMP
2qro – hDCK + UDP + AMP
3ipx – hDCK + ADP + inbhibitor
3ipy – hDCK + inbhibitor
3qej – hDCK (mutant) + UDP
3mjr – hDCK + UDP + hydroxyethoxymethylguanine

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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