Neuraminidase

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Image:3nss.jpg
Crystal Structure of Influenza virus H1n1, 3nss

Template:STRUCTURE 3nss











Neuraminidase (NAN) cleaves the glycosidic bonds of neuraminic acid. The viral NAN is a drug target for prevention of influenza. See also

For other inhibitors see Neuraminidase Inhibitor Pharmacokinetics.

Contents

3D structures of Neuraminidase

Updated on 23-December-2013

Neuraminidase

2ya4, 2w20, 2vvz – SpNANA catalytic domain – Streptococcus pneumoniae
3h71 - SpNANA catalytic domain precursor
2vw0, 2vw1, 2vw2 - SpNANB
2xzi, 2xzj, 2xzk, 2xcy – NANA – Aspergillus fumigatus
2w68 – VcNANA sialic acid binding domain – Vibrio cholerae
1w0o, 1kit– VcNANA
1snt, 1so7 – hNeu2 - human
2f24, 2f26, 2f28 – hNeu2 (mutant)
1eur - MvNANA residues 43-407 – Micromonospora viridifaciens
1euu - MvNANA residues 47-647
1wcq, 1w8n, 1w8o, 2hu0, 2hu4 – MvNANA residues 47-647 (mutant)
3sil – StNANA (mutant) – Salmonella typhimurium

Binary complexes of Neuraminidase

3h72 - SpNANA catalytic domain precursor + sialic derivative
3h73 - SpNANA catalytic domain precursor + sialic acid analog
2ya5 - SpNANA catalytic domain + sialic acid
2ya7, 2ya8 - SpNANA catalytic domain + inhibitor
2ya6 - SpNANA catalytic domain + sialic acid analog
2jkb - SpNANB residues 30-697 + sialic acid analog
4foq, 4fov, 4fow, 4foy, 4fp2, 4fp3, 4fpc, 4fpe, 4fpf, 4fpg, 4fph, 4fpj, 4fpk, 4fpl, 4fpo, 4fpy, 4fq4 – SpNANB + inhibitor
1w0p – VcNANA + sialic derivative
2f0z, 2f10, 2f11, 2f12, 2f13 – hNeu2 + inhibitor
2f25, 2f27, 2f29 - hNeu2 (mutant) + sialic acid analog
1vcu - hNeu2 + sialic acid analog
1eus - MvNANA residues 43-407 + neuraminic acid derivative
2bzd - MvNANA residues 47-647 (mutant) + galactose
1eut - MvNANA residues 47-647 + galactose
2ber - MvNANA residues 47-647 (mutant) + sialic derivative
1dil, 1dim – StNANA + inhibitor
2sim, 2sil - StNANA + neuraminic acid derivative

Influenza virus neuraminidase

3nss, 3k36, 3beq, 3cye, 2cml, 2b8h, 2ht5, 1v0z, 1nn2 – IvNANA residues 82-469 – Influenza virus
4fvk, 4gez - IvNANA residues 76-442
3k38 – IvNANA (mutant)
4gzo, 4k1h, 4k1i, 4k1k - IvNAN N2 residues 77-469
4gzs, 4k1j - IvNAN N2 residues 77-469 (mutant)
2ht5 – IvNAN N8 residues 82-469
2htv - IvNAN N4 residues 82-469
3sal - IvNAN N5 residues 82-469
2hty - IvNAN N1 residues 82-469
3nn9, 4nn9, 5nn9, 6nn9 - IvNAN N9 residues 82-469
7nn9 - IvNAN N9 Tern
2qwa - IvNAN N9 Tern (mutant)
4gdi, 4gdj - IvNAN N10
4b7m - IvNAN H1n1

Binary complexes of Influenza virus neuraminidase

3o9j, 3o9k, 2c4a, 2c4l, 1w1x, 1w20, 1w21, 1nsb, 1nsc, 1nsd – IvNANA + sialic derivative
3k37, 3b7e, 1vcj, 1l7f, 1f8c, 1f8d, 1f8e, 1a4g, 1a4q, 1b9t, 1b9v, 1b9s, 1inf, 1ing, 1inh, 1ivb, 1ivc, 1ivd, 1ive, 1ivf, 1ivg, 4d8s – IvNANA + inhibitor
3ti3, 3ti4, 3ti5, 3ti6 – IvNAN H1n1 + inhibitor
4b7j, 4b7n, 4b7q, 4b7r - IvNAN H1n1 + drug
3tia, 3tib, 3tic – IvNAN H2n2 + inhibitor
1f8b, 1inv, 1inw, 1inx, 1iny, 4gb1 – IvNANA + sialic acid analog
2ht7, 2ht8, 2htq, 2htu – IvNAN N8 + inhibitor
2htr – IvNAN N8 + sialic acid analog
3san, 3ti8 - IvNAN N5 + flu drug
2htw - IvNAN N4 + sialic acid analog
2bat, 4gzw, 4gzx, 4gzq – IvNAN N2 + sialic acid
4gzp, 4gzt - IvNAN N2 + drug
4h52, 4h53 – IvNAN N2 + inhibitor
1nna, 1nnb - IvNAN N9 + neuraminic acid derivative
4dgr - IvNAN N9 + benzoic acid derivative
1xoe, 1xog, 3w09 - IvNAN N9 Tern + inhibitor
2qwb - IvNAN N9 Tern (mutant) + sialic derivative
2qwc, 2qwd, 2qwe - IvNAN N9 Tern (mutant) + sialic acid analog
1mwe - IvNAN N9 Tern + sialic acid
1bji, 1nnc - IvNAN N9 Tern + sialic acid analog
2qwf, 2qwg, 2qwh, 2qwi, 2qwj, 2qwk - IvNAN N9 Tern (mutant) + inhibitor
1nma, 1nmb - IvNAN N9 Tern + mFAB heavy+light chain – mouse
1a14 - IvNAN + mFAB heavy+light chain
1nca, 1ncb, 1ncc, 1ncd - IvNAN N9 + mFAB heavy+light chain
3k39, 3k3a, 3ckz, 3cl0, 3cl2, 1l7g, 1l7h - IvNANA (mutant) + inhibitor
2aep, 2aeq – IvNANA + mFAB heavy+light chain

Endo-neuraminidase

3gvf, 3gvk, 3gvj – ENANA (mutant) residues 246-910 – Enterobacteria phage K1F
3gvl, 3ju4 – ENANA residues 246-910
3gw6 – ENANA residues 790-1064

Pseudaminidase

2w38, 3h6j – PNANA – Pseudomonas aeruginosa

Trans-sialidase

2sli, 1sli, 3sli – lTS + inhibitor – leech

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Eran Hodis

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