Chaperones are proteins that are involved in the non-covalent folding and unfolding of other macromolecules. It exists both in prokaryotes and eukaryotes. Some chaperones are constitutively expressed in the system however, there are other chaperones that are expressed only in response to an external stimulus or stress such as heat and therefore they are referred to as heat shock proteins
[1].
Function
Chaperones bind to the newly synthesized proteins helping them acquire their properly folded 3D structure [2] Besides, chaperones help in targeting the native proteins to their respective organelles [3] Many protozoan parasites such as Plasmodium falciparum requires these proteins for cytoprotection [4] [5]Chaperones actively participate in the maintenance of proteome integrity, and protein homeostasis (proteostasis) which requires a syncrhonization in various chaperones tuning the process [6]
Disease
Relevance
Structural highlights
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