Fatty acid synthase

From Proteopedia

proteopedia linkproteopedia link

Template:STRUCTURE 3tjm

Fatty acid synthase (FAS) catalizes the synthesis of palmitate from acetyl CoA and malonyl CoA into long chain fatty acid. FAS is a multi-domain enzyme. It contains an acyl carrier protein domain (ACP).

Contents 1 3D structures of fatty acid synthase 1.1 FAS 1.2 FAS complex with fatty acid 1.3 FAS complex with reactants 1.4 FAS complex with protein 1.5 FAS complex with inhibitor

3D structures of fatty acid synthase

Updated on 18-August-2014

FAS

1kp9 – MtFAS CmaA1 – Mycobacterium tuberculosis
4bjd, 4bje, 4bjf, 4bjg – MtFAS I – Cryo-EM
3zen, 4b3y – FAS – Mycobacterium smegmatis – Cryo-EM
1xkt – hFAS thioesterase domain – human
2jfd – hFAS MAT domain
3hhd - hFAS KS-MAT domain
2cf2, 2vz8 – pFAS – pig
2uv8, 3hmj – yFAS α+β subunits - yeast
2pff, 2was – yFAS α subunit
2uv9 – TlFAS α subunits – Thermomyces lanuginosus
2uva – TlFAS β subunits
2png – FAS ACP domain – rat
1t8k – EcFAS ACP domain - Escherichia coli
2k92, 2k93, 2k94 - EcFAS ACP domain – NMR

FAS complex with fatty acid

1kpg – MtFAS CmaA1 + cetyl-trimethyl-ammonium + adenosyl homocysteine
1kph – MtFAS CmaA1 + didecyl-dimethyl-ammonium + adenosyl homocysteine
1kpi – MtFAS CmaA2 + didecyl-dimethyl-ammonium + adenosyl homocysteine
3hem - MtFAS CmaA1 + dioctylamine
3tjm – hFAS thioesterase domain + fatty acid
2fae – EcFAS ACP domain + decanethioate
2fad – EcFAS ACP domain + heptanthioate

FAS complex with reactants

2jfk – hFAS + malonyl CoA
2uvc – TlFAS β subunits + NADP
2uvb – TlFAS α subunits + NADP
2wat – yFAS α subunit + CoA
2vz9 – pFAS + NADP

FAS complex with protein

2fhs – EcFAS ACP domain + enoyl-ACP reductase
3ejb - EcFAS ACP domain + biotin biosynthesis cytochrome P450-like enzyme
3ejb, 3eje - EcFAS ACP domain + biotin biosynthesis cytochrome P450-like enzyme + fatty acid
2cg5 - hFAS ACP domain + AASD-PPT

FAS complex with inhibitor

2vkz - yFAS α+β subunits + cerulenin
2px6 – hFAS thioesterase domain + orlistat