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1mdw
From Proteopedia
Revision as of 13:52, 28 September 2014 by OCA (Talk | contribs)
1mdw is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Uncontrolled activation of calpain can lead to necrotic cell death and irreversible tissue damage. We have discovered an intrinsic mechanism whereby the autolysis-generated protease core fragment of calpain is inactivated through the inherent instability of a key alpha-helix. This auto-inactivation state was captured by the 1.9 A Ca(2+)-bound structure of the protease core from m-calpain, and sequence alignments suggest that it applies to about half of the calpain isoforms. Intact calpain large subunits are also subject to this inhibition, which can be prevented through assembly of the heterodimers. Other isoforms or their released cores are not silenced by this mechanism and might contribute to calpain patho-physiologies.
Calpain silencing by a reversible intrinsic mechanism.,Moldoveanu T, Hosfield CM, Lim D, Jia Z, Davies PL Nat Struct Biol. 2003 May;10(5):371-8. PMID:12665854[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
