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This Sandbox is Reserved from 20/01/2015, through 30/04/2016 for use in the course "CHM 463" taught by Mary Karpen at the Grand Valley State University. This reservation includes Sandbox Reserved 987 through Sandbox Reserved 996.

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Contents 1 Oxidosqualene Cyclase 1.1 Introduction 1.2 Structure 1.3 Function 1.3.1 Cholesterol Biosynthesis 1.4 Disease 1.5 Relevance 1.6 Structural highlights 1.7 References

Oxidosqualene Cyclase

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This is a default text for your page '. Click above on edit this page' to modify. Be careful with the < and > signs. You may include any references to papers as in: the use of JSmol in Proteopedia ^[1] or to the article describing Jmol ^[2] to the rescue.

Introduction

Squalene-hopene cyclase uses squalene as a substrate and creates hopene as a product. It is an integral step in the cholesterol biosynthesis pathway. The enzyme is found in many species of bacteria, but most commonly isolated from Alicyclobacillus acidocaldarius. It is considered to be an evolutionary primitive form that operates in the absence of oxygen.

Structure

The protein binds the

Function

Cholesterol Biosynthesis

Cholesterol

Disease

Relevance

Structural highlights

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References

1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644