Function
Dipeptidyl peptidase (DPP) is an enzyme which cleaves dipeptides from polypeptides.
Relevance
DPP-IV level is alternating in certain malignancies.[1] DPP-IV inhibitors control body glucose levels and provide potential advantages in diabetes type 2 therapies.[2]
Disease
DPP-IV is involved in the development of various chronic liver disease like hepatitis C virus infection.[3]
Structural highlights
Human DPP-I contains 3 chains. Light and heavy chains forming the catalytic site and a third chain including the exclusion domain which is responsible of the exopeptidase activity of DPP-I by partially blocking the active site cleft. The inhibitors binds to a Cys residue at the active site. [4]
