From Proteopedia
proteopedia linkproteopedia link Neurotensin Receptor (Rattus norvegicus)
|
Introduction
The neurotensin receptor (NTSR1) belongs to the superfamily of proteins known as G protein-coupled receptors(link to g protein page in proteopedia) and responds to the 13 amino acid hormone nuerotensin (NT). G protein-coupled receptors are involved in a large array of physiological processes within the body and are a major site of drug targets in medicine. (reference)
Neurotensin
Structure
Overall Structure
Neurotensin Binding Site
Hydrophobic Stacking
Sodium Binding Pocket
Allosteric Effects
This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
|
References
Fredriksson, Robert, et al. "The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints." Molecular pharmacology 63.6 (2003): 1256-1272.
Gui, Xianyong, and Robert E. Carraway. "Enhancement of jejunal absorption of conjugated bile acid by neurotensin in rats." Gastroenterology 120.1 (2001): 151-160.
Binder, Elisabeth B., et al. "Neurotensin and dopamine interactions." Pharmacological reviews 53.4 (2001): 453-486.