From Proteopedia
proteopedia linkproteopedia link Neurotensin Receptor (Rattus norvegicus)
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Introduction
The neurotensin receptor (NTSR1) belongs to the superfamily of proteins known as G protein-coupled receptors(link to g protein page in proteopedia) and responds to the 13 amino acid hormone nuerotensin (NT). There are currently around 800 G protein-coupled receptors that have been identified and they are thought to be responsible for roughly 80% of signal transduction across the cell membrane.(reference (year in g protein) These receptors are involved in a vast array of physiological processes within the body and are a major site of drug targets in medicine. (reference 5 main families)
Neurotensin
Structure
Overall Structure
Neurotensin Binding Site
Hydrophobic Stacking
Sodium Binding Pocket
Allosteric Effects
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References
Millar, Robert P., and Claire L. Newton. "The year in G protein-coupled receptor research." Molecular endocrinology 24.1 (2010): 261-274.
Fredriksson, Robert, et al. "The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints." Molecular pharmacology 63.6 (2003): 1256-1272.
