User:Eric Martz/Protein 3D Structure Resources for Educators 2016

• Introduction to Structural Bioinformatics 2016
• Designed for undergraduate biological science majors (4 hours/afternoon x 3 afternoons = 12 lab hours)
• Each student picks a different protein and does a report on how its structure supports its function
• Sample Completed Report Section 9 is obsolete since animations can now be saved directly from FirstGlance

Tutorials on Specific Macromolecules

• In a computer lab, I like to hand out a short list of somewhat vague, open-ended questions to foster discussion in small groups of students. See Worksheets.
• Most of these tutorials are in Proteopedia.Org, a wiki with user-authored content. Some articles are authored by students. As with Wikipedia, use your judgement. Unlike Wikipedia, authors' real names are at the bottom of each article and you can check their credentials by clicking on the names.

Molecules With Questions For Students (Java not needed)

• DNA. Español (B form double helix) - A Nonlinear Tutorial / Discovery Tool
  • Linear tutorial on DNA
• Lac Repressor binding to DNA and bending the operon. Questions for Students.

Molecules With No Questions ... Yet

No Java Needed

• Carbohydrates, lipids, vitamins, proteins, and nucleic acids. Español.
• Myosin
• Hemoglobin
• Antibody
• Ion Channels
  • Potassium Channels
  • Voltage-gated calcium channels
  • Mechanosensitive channels: opening and closing (animation)
• Avian Influenza Neuraminidase, Tamiflu and Relenza
  • Short animation: Molecular_Playground/Tamiflu
• HIV-1 protease
  • HIV Protease Inhibitor with simulation of binding with induced fit - ENLARGED for projection
• Lipid Bilayers and the Gramicidin Channel
  • Short version: Gramicidin Channel in Lipid Bilayer - Español
• Collagen
• Nucleosome structure
• Ribosome

• Water including liquid water and ice, and a simulation of hydrogen-bond formation.
• SV40 Virus Capsid Simplified
• Thermal motion of peptide, molecular dynamics simulation
• Dramatic conformational change induced by calcium: Recoverin, a calcium-activated myristoyl switch

Tutorials requiring Java (fussy)

Getting Java to work with the unsigned applets in these older tutorials is too fussy for most students, but these could be shown in lectures.

• At MolviZ.Org: Hemoglobin, Antibody, Major Histocompatibility Complex. A different approach than the ones in Proteopedia.

Molecule of the Month

These articles are authored by David S. Goodsell (The Scripps Research Institute and the RCSB PDB), a well-respected structural biologist.

• Molecule of the Month has articles on many macromolecules, including
  • Myosin
  • Potassium Channels
  • Acetylcholine Receptor
• Molecules of the Month can be explored interactively, in more detail, by entering the 4-character PDB codes given near the end of each article into FirstGlance.Jmol.Org.

Make Your Own Tutorials

• Proteopedia.Org has Molecular Scene Authoring Tools that make it easy to create web pages with interactive macromolecules. Start at Help:Getting Started in Proteopedia and the Video Guides. Don't hesitate to ask for help from me!
• Or you can add to any existing tutorial, or copy it and adapt it to your needs.

For Researchers

• A June 2016 workshop for researchers. Previous workshop syllabi at Workshops.MolviZ.Org.

See Also

• Teaching Strategies Using Proteopedia
• Atlas of Macromolecules: Atlas.MolviZ.Org.
• High school teachers' resources including DNA earrings and balloon molecules.
• Molecular Workbench from Concord Consortium. Requires Java but has assessment tools built in.
• Molecular Playground. An installation is planned for a high school in Springfield, and one is already in service at the Springfield Science Museum.