Ribosomal protein L5

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Contents 1 Function 2 Relevance 3 3D Structures of Ribosomal protein L5 4 References

Function

Ribosomal protein L5 (RPL5) is one of the 34 proteins which belong to the of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. It is known to bind to the 5S RRNA from the large subunit. In the archaea like in Haloarcula marismortui, the L5 is called L5P (RPL5P).

Relevance

Mutations in RPL5 are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients^[1].

3D Structures of Ribosomal protein L5

Updated on 14-August-2016

5aff – RPL5 + RPL11 + symportin – Chaetomium thermophilum

References

1. ↑ Bransteitter R, Pham P, Scharff MD, Goodman MF. Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4102-7. Epub 2003 Mar 21. PMID:12651944 doi:http://dx.doi.org/10.1073/pnas.0730835100