Ribosomal protein L5

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Contents 1 Function 2 Relevance 3 3D Structures of Ribosomal protein L5 4 References

Function

Ribosomal protein L5 (RPL5) is one of the 34 proteins which belong to the of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. It is known to bind to the 5S RRNA from the large subunit. In the archaea like in Haloarcula marismortui, the L5 is called L5P (RPL5P).

Relevance

Mutations in RPL5 are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients^[1].

3D Structures of Ribosomal protein L5

Updated on 14-August-2016

5aff – RPL5 + RPL11 + symportin – Chaetomium thermophilum

References

1. ↑ Gazda HT, Sheen MR, Vlachos A, Choesmel V, O'Donohue MF, Schneider H, Darras N, Hasman C, Sieff CA, Newburger PE, Ball SE, Niewiadomska E, Matysiak M, Zaucha JM, Glader B, Niemeyer C, Meerpohl JJ, Atsidaftos E, Lipton JM, Gleizes PE, Beggs AH. Ribosomal protein L5 and L11 mutations are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients. Am J Hum Genet. 2008 Dec;83(6):769-80. PMID:19061985 doi:S0002-9297(08)00589-2