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Anopheles arabiensis Insulin Receptor like Protein

spinqualitylabelsall models Anopheles arabiensis InR kinase domain model Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Anything in this section will appear adjacent to the 3D structure and will be scrollable.

The Anopheles arabiensis Insulin Receptor's kinase domain was modeled by Brian Pierce for the 'An arab ts lethal project'

This shows the basic structure of the kinase domain with an . The ATP will sit between them just below Beta 1

shows the ATP binding site (purple) and the catalytic loop (green). Here it is as a .

These are found in other RTKs.

G1000S (magenta), A1133G (orange), T1221I (teal)

And as a

This when mutated to isoleucine resulted in ts lethal mutations in the sevenless and EGFR-like genes in D. melanogster

Using the software TS_pred (a ts mutation prediction program): these are the to mutate based on sequence and structure - L1236, I1071, V1196, L1197,I1258 (red) Using Rosetta_ts_rbf (another ts mutation prediction program): these are the sites -W1173P, M1075K, Y1208G, L1197P, Y1208Asn (yellow)

Both TS_pred and Rosetta_ts_rbf had in their top 5 (black)

Most but not all of the actual and predicted mutations are . Note that T1221 and G1000S are not buried.

Here are the .

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