From Proteopedia
proteopedia linkproteopedia link==DNA Gyrase== 0
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You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue.
== Function == DNA Gyrase is a protein located mainly in Prokaryotes, specifically bacteria. It falls under the Topoisomerase family and can be referred to as Topoisomerase II. It is responsible for negatively induced supercoiling. This method of supercoiling is used to reduce the strain caused by the twists in DNA. It aids in compaction, as well as separation of DNA. As one can see, it plays a significant role in prokaryotes.
== Disease == Researches specifically study this protein for multiple reasons. It could possibly help with antibacterial chemotherapy.
Relevance
== Structural highlights == The structure of DNA Gyrase consists of mainly two subunits. This First known as A contains the tyrosine which is responsible for cleavage. The second subunit B is responsible to the binding of ATPase’s active site. Both subunits work together to produce the negative supercoiling produced in DNA strands.
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== References == Schoeffler, A. J., May, A. P., & Berger, J. M. (2010). A domain insertion in Escherichia coli GyrB adopts a novel fold that plays a critical role in gyrase function. Nucleic Acids Research, 38(21), 7830-7844. doi:10.1093/nar/gkq665
Rahimi, H., Najafi, A., Eslami, H., Negahdari, B., & Moghaddam, M. M. (2016). Identification of novel bacterial DNA gyrase inhibitors: An in silico study. Journal Of Research In Pharmaceutical Sciences, 11(3), 250-258.
Travers, A., & Muskhelishvili, G. (2015). DNA structure and function. FEBS Journal, 282(12), 2279-2295. doi:10.1111/febs.13307
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
