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This Sandbox is Reserved from November 5 2018 through January 1, 2019 for use in the course "CHEM 4923: Senior Project taught by Christina R. Bourne at the University of Oklahoma, Norman, USA. This reservation includes Sandbox Reserved 1471 through Sandbox Reserved 1478.
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PDB ID 3AIE
This enzyme is a glucansucrase from Streptococcus mutans.[1]. These enzymes are large and extracellularly expressed by few other bacterial species.[2]. Their main function is to catalyze the production of glucose polymers from sucrose substrates.[1]. These polymers comprise the dental plaque that promotes tooth decay in humans. For this reason, knowledge of the structure, genome, and proteome of this enzyme is critical for the development of an inhibitor in an effort to reduce the prevalence of cavities and periodontal disease.
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Structure
Function
Disease
Relevance
Based on the enzyme's contributions to dental cavity formation, this enzyme and its genes are attractive targets for inhibition.
References
- ↑ 1.0 1.1 Ito K, Ito S, Shimamura T, Weyand S, Kawarasaki Y, Misaka T, Abe K, Kobayashi T, Cameron AD, Iwata S. Crystal Structure of Glucansucrase from the Dental Caries Pathogen Streptococcus mutans. J Mol Biol. 2011 Feb 25. PMID:21354427 doi:10.1016/j.jmb.2011.02.028
- ↑ Leemhuis H, Pijning T, Dobruchowska JM, van Leeuwen SS, Kralj S, Dijkstra BW, Dijkhuizen L. Glucansucrases: three-dimensional structures, reactions, mechanism, alpha-glucan analysis and their implications in biotechnology and food applications. J Biotechnol. 2013 Jan 20;163(2):250-72. doi: 10.1016/j.jbiotec.2012.06.037. Epub, 2012 Jul 10. PMID:22796091 doi:http://dx.doi.org/10.1016/j.jbiotec.2012.06.037
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