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| This Sandbox is Reserved from May 28 through July 01, 2019 for use in the course Advanced Biochemistry BCHM 4100 taught by Tom Gluick at the Georgia Gwinnett College. This reservation includes Sandbox Reserved 1544 through Sandbox Reserved 1555.
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Enoyl-coa hydratase complexed with octanoyl-coa
Alternative names: Enoyl hydrase, Unsaturated acyl-CoA hydratase.Cocrystallized with octanoyl-coa.The structure of the hexameric rat mitochondrial enoyl-Coenzyme A (CoA) hydratase, co-crystallised with the inhibitor octanoyl-CoA
The source of the sample from organism: is from mitochondrial Cell of iver of Norway rat, Rattus norvegicus. Organism_taxid: 10116.
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Structural Highlights
2dub is a 6 chain structure with sequence from [1]. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
| | Ligands: | |
| Activity: | Enoyl-CoA hydratase, with EC number 4.2.1.17 | | Gene:</td> | dbh, dpo4, SSO2448 (ATCC 35091)</td></tr>
| | Activity:</td> | DNA-directed DNA polymerase, with EC number 2.7.7.7 | | Related:</td>
| | Gene: | dbh, dpo4, SSO2448 (ATCC 35091)
| | Activity:</td> | DNA-directed DNA polymerase, with EC number 2.7.7.7 </td></tr>
| | Resources:</td> | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT</td></tr>
</table>
Length: 261 amino acids, Specific chains of 2-enoyl-coa hydratase are: a, b, c, d, e, f . 6 chain structure with sequence from Rattus norvegicus. ligand: CO8. The catalytic water is bound between Glu144 and Glu164 in the hydratase.
Function
Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate. The chains homologous to 2DUB: 1DUB, 1EY3.
(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O
Disease
Dysfunctional MFE2 is one of the most common reasons of peroxi- somal disorder in humans
Relevance
== References ==
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