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Contents 1 Leptospira cAMP-dependent DGC 1 (Lcd1) 2 Introduction 3 Function 4 Disease 5 Relevance 6 Structural highlights 7 References

Leptospira cAMP-dependent DGC 1 (Lcd1)

spinqualitylabelsall models Lcd1 GAF domain in complex with cAMP ligand. Method: X-Ray Diffraction. Resolution: 2.15 Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Introduction

The leptospirosis is caused by pathogenic species bacterias of generum Leptospira and is a emerging zoonotic disease worldwide ^{[1] [2]}.

Estima-se que 1 milhão de pessoas se infectam com leptospira por ano e 60.000 morrem da doença no mundo (Costa et al., 2015; revisado por Picardeau, 2017). A incidência é maior nos países tropicais, pois o clima e a umidade favorecem a proliferação desta bactéria. In 5–15% of leptospirosis cases, the clinical symptoms may progress to a severe disease condition, which can cause jaundice, renal failure, meningitis, hypotension, bleeding, multiple organ failure, pulmonary hemorrhages and, in some cases, death [21,22]. The ability of some Leptospira species to grow in different conditions, such as in soil, water, and in different mammalian organs and the bloodstream, suggests that the bacteria should possess different signaling pathways to sense the external environment in order to appropriately modify bacterial biochemistry, physiology, and behavior. Therefore, we can expect that c-di-GMP will have an important role in the Leptospira life cycle. However, to date, almost nothing is known about c-di-GMP signaling in Leptospira.

Function

Disease

Relevance

Structural highlights

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References

1. ↑ da Costa Vasconcelos FN, Maciel NK, Favaro DC, de Oliveira LC, Barbosa AS, Salinas RK, de Souza RF, Farah CS, Guzzo CR. Structural and Enzymatic Characterization of a cAMP-Dependent Diguanylate Cyclase from Pathogenic Leptospira Species. J Mol Biol. 2017 Jul 21;429(15):2337-2352. doi: 10.1016/j.jmb.2017.06.002. Epub, 2017 Jun 7. PMID:28601495 doi:http://dx.doi.org/10.1016/j.jmb.2017.06.002
2. ↑ Vincent AT, Schiettekatte O, Goarant C, Neela VK, Bernet E, Thibeaux R, Ismail N, Mohd Khalid MKN, Amran F, Masuzawa T, Nakao R, Amara Korba A, Bourhy P, Veyrier FJ, Picardeau M. Revisiting the taxonomy and evolution of pathogenicity of the genus Leptospira through the prism of genomics. PLoS Negl Trop Dis. 2019 May 23;13(5):e0007270. doi:, 10.1371/journal.pntd.0007270. eCollection 2019 May. PMID:31120895 doi:http://dx.doi.org/10.1371/journal.pntd.0007270