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Background
Structure
Domains
Three Helix Bundle-like Domain
The three helix bundle-like domain mainly has a structural function overall as it interacts with the tumor necrosis factor-like domain upon ligand binding.
Poly-Glycine Domain
Located between the three helix bundle-like domain and the tumor necrosis factor-like domain, the poly-glycine domain has an important structural role.
Tumor Necrosis Factor-like Domain
The tumor necrosis factor-like domain interacts with the three helix bundle-like domain to begin the conformational changes associated with ligand binding. The three helix bundle-like domain's alpha helix interacts with the helix alpha-1' and beta strand A-1'. This domain also assists in mediating ligand binding with the epidermal growth factor-like domain.
Epidermal Growth Factor-like Domain
The epidermal growth factor-like domain is very malleable and repositioning of this domain is essential for activation of the protein. This domain is able to undergo conformational changes with the ligand bound and when in contact with the tumor necrosis factor-like domain.
Function
Disease
Relevance
Structural highlights
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