MRGPRX2 is a GPCR that is located in the cellular membranes of mast cells. It shares the same structural features of all GPCR's which include a and a domain. The G-protein domain consists of , , and subunits.

Background

Ligands

Significance

Structure

Heterotrimeric G-Protein Structure

Novel Characteristics

The most important findings about the MRGPRX2 receptor are the differences between it and all other previously discovered GPCR's found in the A family. Many conserved structural motifs, characteristic of the A family receptors, are absent on MRGPRX2, which contribute significantly to the different ligand interactions it has.

Toggle Switch

Previously known Tryptophan residue that acts as the Toggle Switch in GPCR is switched to a .

Sodium Site

PIF/LLF Motif

LLF Motif on .

DRY/ ERC Motif

Disulfide Bonds

Disulfide bond connecting .

Further Information

Function

Before Activation

After Activation

Clinical Relevance

3D Structures

</Structure Section>

References