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Methionine synthase

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Methionine synthase

B-12 dependent fragment of E. coli methionine synthase with Cobalt (in pink)

Drag the structure with the mouse to rotate

Vitamin B-12

Oxidation States of Cobalamin

Co(I) - active, unstable, high energy

Co(II) - common oxidation state

Relevance

Methionine deficiency can result in diseases such as birth abnormalities.

References

[1]

  1. ↑ Barra L, Fontenelle C, Ermel G, Trautwetter A, Walker GC, Blanco C. Interrelations between glycine betaine catabolism and methionine biosynthesis in Sinorhizobium meliloti strain 102F34. J Bacteriol. 2006 Oct;188(20):7195-204. doi: 10.1128/JB.00208-06. PMID:17015658 doi:http://dx.doi.org/10.1128/JB.00208-06

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Kia Yang, Karsten Theis, Michal Harel, Anna Postnikova, Michael O'Shaughnessy

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