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Function

Disease

Relevance

Structure

SHOC2

SHOC2 is a domain which acts as a cradle to bind PP1C and MRAS. The is a leucine rich repeat (LRR) protein that consists of 20 consecutive . This motif results in an extended beta sheet on the inner concavity of the protein surface with alpha helices facing outward. This results in a largely hydrophobic core.

MRAS

binds to SHOC2 primarily by the descending loop and strands of each LRR domains 2-10. Once associated with SHOC2, it binds to PP1C and guides the holoenzyme complex to the cell membrane to begin signaling.

PP1C

protein phosphatase 1 catalytic subunit (PP1C) is highly characterized of serine/ threonine phosphatase. associates with the ascending loops of the SHOC2 LRR regions.

Interactions

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