5en6

Structural highlights

Function

SMU1_CAEEL Involved in pre-mRNA splicing as a component of the spliceosome (By similarity). Selectively regulates alternative splicing of unc-52 exon 17 (PubMed:11438655, PubMed:15254247). Thus, smu-1 mutants selectively suppress the effects of unc-52 nonsense mutations in exon 17 by promoting the accumulation of unc-52 isoforms that lack exon 17 and enhance the effects of unc-52 mutations that affect the exon 16 splice donor site (PubMed:11438655, PubMed:15254247). In contrast, smu-1 mutants do not suppress unc-52 nonsense mutations in exon 18 (PubMed:11438655).[UniProtKB:Q2TAY7]^{[1] [2]}

References

1. ↑ Spike CA, Shaw JE, Herman RK. Analysis of smu-1, a gene that regulates the alternative splicing of unc-52 pre-mRNA in Caenorhabditis elegans. Mol Cell Biol. 2001 Aug;21(15):4985-95. PMID:11438655 doi:10.1128/MCB.21.15.4985-4995.2001
2. ↑ Spartz AK, Herman RK, Shaw JE. SMU-2 and SMU-1, Caenorhabditis elegans homologs of mammalian spliceosome-associated proteins RED and fSAP57, work together to affect splice site choice. Mol Cell Biol. 2004 Aug;24(15):6811-23. PMID:15254247 doi:10.1128/MCB.24.15.6811-6823.2004