Erythrocyte binding antigen

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spinqualitylabelsall models EBA region II (mutant) complex with sulfate and Cl- ion (PDB code 1zro) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Erythrocyte binding antigen or Duffy receptor (EBA) is a Plasmodium ligand which binds to erythrocytes. Some strains are dependent on sialic acid for binding[1]. EBA-175 is a Plamodium ligand that binds to human erythrocytes glycophorin A in a sialic acid-dependent manner[2]. EBA-140 is a Plamodium ligand that binds to human erythrocytes glycophorin C [3]. For more details see Malaria Parasite Plasmodium falciparum Erythrocyte Binding Antigen 140.

3D Structures of erythrocyte binding antigen

Updated on 19-June-2024

References

1. ↑ Lin DH, Malpede BM, Batchelor JD, Tolia NH. Crystal and Solution Structures of Plasmodium falciparum Erythrocyte-binding Antigen 140 Reveal Determinants of Receptor Specificity during Erythrocyte Invasion. J Biol Chem. 2012 Oct 26;287(44):36830-6. doi: 10.1074/jbc.M112.409276. Epub 2012, Sep 18. PMID:22989878 doi:10.1074/jbc.M112.409276
2. ↑ Duraisingh MT, Maier AG, Triglia T, Cowman AF. Erythrocyte-binding antigen 175 mediates invasion in Plasmodium falciparum utilizing sialic acid-dependent and -independent pathways. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4796-801. PMID:12672957 doi:10.1073/pnas.0730883100
3. ↑ Lin DH, Malpede BM, Batchelor JD, Tolia NH. Crystal and Solution Structures of Plasmodium falciparum Erythrocyte-binding Antigen 140 Reveal Determinants of Receptor Specificity during Erythrocyte Invasion. J Biol Chem. 2012 Oct 26;287(44):36830-6. doi: 10.1074/jbc.M112.409276. Epub 2012, Sep 18. PMID:22989878 doi:10.1074/jbc.M112.409276