User:James Lignos/Sandbox 1

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Bromodomain of PfBDP1

In 2023, globally, there were an estimated 263 million new malaria cases and 597,000 deaths. Plasmodium falciparum, the causative parasite of malaria, invade red blood cells and consumes hemoglobin, preventing oxygen transport to the heart, resulting in heart failure. Additionally, parasitized RBCs stick to the wall of blood vessels in the heart and brain to evade the immune system, which leads to inflammation and blood vessel blockage to these vital organs thus, it is imperative to understand the essential factors involved in the P. falciparum RBC invasion process to develop therapeutic interventions.

spinqualitylabelsall models PDB ID 9HHD. Plasmodium Falciparum Bromodomain Containing protein 1 complexed with bromodomain inhibitor RMM2. MW 16.09 kDa res.325-456 2.69Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

spinqualitylabelsall models PDB ID 1stp Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Disease 3 Relevance 4 Structural highlights Function Binds acetylated lysines at promoters of genes implicated in host cell invasion Disease Relevance Structural highlights This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

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